SKU: 83214157603

Biotinylated LILRB4/CD85K/ILT3 Fc&Avi Tag Protein, Human

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Description

Biotinylated LILRB4/CD85K/ILT3 Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms LIR5,HM18,ILT 3 Accession Q8NHJ6 Amino Acid Sequence Gln22 Glu259 with hIgG1 Fc&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 55 70kDa (Reducing) Purity 95% by SDS PAGE & > 95% RP HPLC Conjugation Biotin Tag Avi Tag, Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in

Product Specification


Species Human
Synonyms LIR5,HM18,ILT-3
Accession Q8NHJ6
Amino Acid Sequence

Gln22-Glu259 with hIgG1 Fc&Avi Tag at the C-Terminus
Expression System HEK293
Molecular Weight 55-70kDa (Reducing)
Purity ＞95% by SDS-PAGE & > 95% RP-HPLC
Conjugation Biotin
Tag Avi Tag, Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Zhou Y, Li Y, He Q, Kong Z, Yu R, Yu X, Xie A. Uncovering the Associations of LILRB4 Genotypes With Parkinson's Disease: From Clinical Traits to Potential Pathologies. CNS Neurosci Ther. 2025 Jul;31(7):e70522.
2.Zhang N, Wang Q, Chen G, Liu L, Wang Z, Ma L, Liang Y, Wu J, Li X, Liu X, Zhou F. Jab1 promotes immune evasion and progression in acute myeloid leukemia models under oxidative stress. J Clin Invest. 2025 Aug 5;135(20):e183761. 
3.Wang H, Ji S, Zhang J, Li C, Meng X, Sun Y, Wang L, Luan H, Li F, Hui L, Li F, Wei S, Yu H, Li Z. LILRB4 specific overexpression in myeloid cells promotes tumor progression and immunosuppression in mouse models. Biochem Biophys Res Commun. 2025 Apr 1;755:151536.

Background

ILT3 (also known as LILRB4/CD85k/LIR-5) is an approximately 60 kDa transmembrane glycoprotein containing two immunoglobulin-like domains in its extracellular region and three ITIM inhibitory motifs in its intracellular region, with a secreted isoform detectable in serum. This protein is primarily expressed in myeloid cells such as monocytes and dendritic cells, as well as vascular endothelial cells. By recognizing MHC class I molecules and transmitting inhibitory signals, it negatively regulates immune cell activation and can induce the generation of CD8⁺ suppressor T cells, thereby promoting immune tolerance. Clinically, ILT3 is involved in suppressing transplant rejection, while the upregulation of its soluble form in the tumor microenvironment is associated with immune evasion, making it a potential target for immunotherapy.

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SKU: 83214157603

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4.8 ★★★★★
Based on 19 reviews
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Product Reviews
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Verified Purchase
Bernadette Smith
Lowell, US
★★★★★ 5
Excellent Rivals to Lovers!!
Format: Kindle
The tension and banter between Huntyr and Wold was delectable. I absolutely love the fallen angel and all of his flaws. Huntyr is amazing too being a badass FMC with some major trauma. The world building was great and I enjoyed the training aspect of the story. The writing was immersive and was in the story the whole time. The ending had quite a twist that I hadn’t anticipated and made my jaw DROP. Excellent job! I also loved the narration. Laura is one of my fave narrators!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 15, 2025
E
Verified Purchase
❈ Elizabeth ❈ | Breakawayreads
Alexandria, US
★★★★★ 5
Fallen Angels, fae, vampires, oh my!
Format: Kindle
Rating: 4.5 | Spice: 2 (but a good slow-burn) • Main Characters: Huntyr and Wolf • I couldn’t wait to read this book; there was so much hype about it! And there was no doubt why. I fell in love with the characters and the plot itself. This book is mainly plot driven more than friction driven but it’s easy to follow along with. The characters are fun, easily understood. The main setting is at an academy where both the main characters are going through trials and building strength for the final test, The Transcendent. There are fantastic side characters as well. I loved the camaraderie between Huntyr and her friends. But we don’t like Lanson. 😆 We do have some plot twists that come into play throughout the book. Secrets and betrayal to be seen. I did adore Wolf and Huntyr’s relationship. It was a classic slow burn trope. They didn’t hit it off fast, but in time their feelings grew. I loved their banter, so sexy. Wolf is your next book boyfriend; Huntyr is your next vampire assassin independent bad-a*s female. Themes include loyalty, trust, self-discovery, a true slow burn romance. Side note: book ends on a angsty cliffhanger! • Emily, thank you for writing this awesome novel and I cannot wait to devour Book 2, Blood So Brutal! 😍 • Happy reading, my lovelies! xo
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Reviewed in the United States on January 21, 2024
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Verified Purchase
MelsABookworm
Lexington, US
★★★★★ 4
“My heart bows to you and you only, Huntress.”
Format: Kindle
3.5 🌟 This book popped up in my KU recommended reading suggestions and the synopsis sounded like what I was in the mood for. I'm so glad I took a chance on it. I went into this knowing absolutely nothing about it and ended up really liking it. I love when this happens. The main characters are likeable and I easily found myself rooting for them. There is a mystery element to each of their backstories that I enjoyed watching unfold and can't wait to get more of. Wolf, in particular, has me fixated. Love him. I found this to be an entertaining, addictive read with a plot that moves along at a good pace. It reads so easily I found myself very reluctant to put it down. Lots of twists and turns and the angst is there. A good set up for the next book to come, for sure. My issues with this book....the dialogue feels a bit juvenile at times and there is a repetitive over use of a particular word phrasing that I found myself giving the ole eye-roll to. There are, without a doubt, some pretty cliche moments that gave me a bit of the cringe. I think this could've certainly 100% benefited from more depth regarding the world building. Perhaps the world building was sacrificed to keep the pacing quick? Just a guess. Also, the lack of consistency of character for the FMC was really evident and so she feels quite illogical at times. Overall, this was a fun and enjoyable read that hit the spot well enough for me. That ending certainly has me impatiently pining for book 2!
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Reviewed in the United States on June 18, 2024
A
Verified Purchase
Amazon Customer
Bozeman, US
★★★★★ 3
Interesting take on the genre
Format: Kindle
True rating: 3.25 ⭐️ I enjoyed the fresh take on the genre. The best way I could describe the setting and world is an apocalyptic dystopian version of Farie where vampires, fae, and angles struggle to survive in what is left of the world. It was definitely interesting throwing the academy/hunger games aspect into this world as well. Even though I guessed the final reveal early on in the book, I kept hoping I was wrong, and it would take a surprising turn. While the "plot twists" were a bit predictable to me, I still enjoyed the ride this book took me on. Another downfall for me was the plot holes in the world building... I.E. if society has fallen and the world is in the aftermath of war, how are there trains running around the world? Just to take young adults to the trials to get into the golden city? How is the train maintained, the tracks clear, etc? However, I did enjoy the FMC & MMC and thought they were fleshed out nicely. I also enjoyed the side characters but wish some were developed more like Ashalin (sp?). I do find myself rooting for the MCs to succeed and find happiness together, which is obviously an important aspect for romantasy. Overall, was this an earth-shattering, mind-bending, terrific piece of literature? No. But was it the worst thing I've read this year? Also, no. This book has, to me, the bones of a great read & just needs a bit more to push it from an alright book to a great book. Overall ratings: Plot- 3.5⭐️ World building 3⭐️ Spice 2.5 🌶🌶 Main characters 4 ⭐️ Supporting characters 3.5⭐️
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Reviewed in the United States on May 12, 2024
I
Verified Purchase
Irene zamora
Grantham, US
★★★★★ 5
great book
Format: Kindle
I am really excited to meet the author at the book retreat this month. I really enjoyed this world that she built and most of the female main character Huntress is so awesome. She goes through a lot in this book and the ending; wow! I wouldn't have even guessed. I highly recommend everyone to read this book. I have been so lucky this year that almost all the books I have read have been, so far, 5 out 5 stars.
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Reviewed in the United States on June 2, 2026

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